Wegener's Granulomatosis & Microscopic Polyangiitis

Wegener's Granulomatosis Treatment at IRIS
ANCA-Associated Vasculitis

Understanding Wegener's Granulomatosis & Microscopic Polyangiitis: Symptoms, Diagnosis & Advanced Care

Wegener's Granulomatosis (Granulomatosis with Polyangiitis - GPA) and Microscopic Polyangiitis (MPA) are rare autoimmune inflammatory disorders that cause necrotizing vasculitis of small and medium-sized blood vessels. These conditions typically affect the upper respiratory tract, lungs, and kidneys, causing granuloma formation, tissue destruction, and organ damage. Early diagnosis and targeted treatment are crucial to managing symptoms, preventing organ failure, and improving quality of life. At IRIS Centre for Rheumatology, we offer world-class, patient-centric care for ANCA-associated vasculitis using the latest advances in rheumatology.

GPA and MPA can affect anyone at any age, but they most commonly occur in middle-aged adults (40-60 years). Both conditions are strongly associated with ANCA antibodies (c-ANCA/PR3 for GPA, p-ANCA/MPO for MPA). At IRIS, our multidisciplinary team ensures comprehensive management from early diagnosis to long-term remission strategies.

With our state-of-the-art immunodiagnostic laboratory, advanced imaging, and personalized treatment plans — including immunosuppressants, corticosteroids, and biologic agents — we aim to halt disease progression, relieve symptoms, and prevent organ damage. Healing begins with expert care and compassion.

Wegener's Granulomatosis Symptoms

Common Symptoms of GPA & Microscopic Polyangiitis

GPA and MPA symptoms can affect multiple organs. Early recognition leads to better outcomes.

  • Chronic sinusitis, bloody nasal discharge, nasal crusting
  • Ear infections, hearing loss, saddle nose deformity
  • Cough, hemoptysis (bloody sputum), shortness of breath
  • Hematuria (bloody urine), proteinuria (kidney involvement)
  • Joint pain, skin rashes (palpable purpura)
  • Mononeuritis multiplex (nerve damage)

Diagnosis at IRIS

Early and accurate diagnosis is key to controlling GPA and MPA. Our advanced diagnostic tools include:

  • Comprehensive clinical examination & organ assessment
  • Blood tests: ANCA (c-ANCA/PR3 for GPA, p-ANCA/MPO for MPA), ESR, CRP
  • Urinalysis for kidney involvement
  • Chest imaging (X-ray, CT) for lung involvement
  • Tissue biopsy (kidney, lung, nasal) for definitive diagnosis

Advanced Treatment Options

We tailor treatments to achieve remission and improve life quality.

  • High-dose corticosteroids for rapid inflammation control
  • Cyclophosphamide for induction of remission
  • Rituximab (biologic) for induction and maintenance
  • Methotrexate or Azathioprine for maintenance therapy
  • Plasmapheresis for severe kidney involvement
  • Regular monitoring of disease activity and organ function

Why Choose IRIS for GPA & Microscopic Polyangiitis Care?

  • Expert rheumatologists with 13+ years experience
  • ISO 9001:2015 Certified & NABH accredited lab
  • On-site ANCA testing and immunodiagnostics
  • Personalized immunosuppressive therapy monitoring
  • Integrated nephrology, pulmonology, and ENT care
  • Compassionate, patient-centric approach
  • Over 2000+ patients successfully treated
  • Multidisciplinary care for systemic involvement


IRIS Centre for Rheumatology Kollam
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